anti tap 1 (Proteintech)
Structured Review
Anti Tap 1, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 47 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/anti+tap+1/TAP1+Antibody/pm40680611-227-7-9
Average 94 stars, based on 47 article reviews
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other:Article Title: Carnosic Acid: A Novel Selective Inhibitor of ERAP1 by Direct Binding and Its Modulation of Antigen Processing and Presentation. Article Snippet: ERAP1 is an emerging target for a large subclass of severe autoimmune diseases known as “MHC-I-opathy”, together with tumor immunity.. Nevertheless, effective inhibitors targeting ERAP1 remain a challenge.. In this study, a novel food-derived natural product ERAP1-targeting inhibitor, carnosic acid, was identified, and to our knowledge, it is one of the best active compounds among the highly selective inhibitors targeting the orthosteric site of ERAP1. Article Title: Corilagin regulates antigen processing and presentation by directly binding to inhibit ERAP1. Article Snippet: ERAP1 is a critical aminopeptidase that acts as the final “editor” of endogenous antigen peptides in the endoplasmic reticulum, playing a key role in the MHC-I-mediated antigen processing and presentation pathway.. It has become a novel target for a broad class of severe autoimmune diseases, referred to as “MHC-I-opathy,” as well as for tumor immune evasion.. Here, we report the discovery of a food-derived natural product inhibitor, Corilagin, with a novel scaffold that directly interacts with ERAP1, identified through high-throughput screening. Western Blot:Article Title: STING agonist-based ER-targeting molecules boost antigen cross-presentation. Article Snippet: The following fluorescent conjugate-labeled antibodies were used: FITC-anti-CD11c (BioLegend, 117306); PE-anti-CD11b (BioLegend, 101207); APC/Cy7-anti-CD62L (BioLegend, 104427); PB-anti-CD44 (BioLegend, 156005); BV650-anti-CD127 (BioLegend, 135043); APC-antiCD24 (BioLegend, 138505); PerCP/Cy5.5-anti-CD172α (BioLegend, 144010) ; PE/Cy7-anti-B220 (BioLegend, 103222); PB-anti-CD86 (BioLegend,105007); BV421-anti-CD86 (BioLegend, 105032); APC-anti-H-2Kb-SIINFEKL (BioLegend, 141606); PE-anti-H2-Kb-SIINFEKL (1:100, BioLegend, 141603); PE/Cy7-anti-H-2Kb-SIINFEKL (BioLegend,141607); PE-anti-H2-Kb-SIINFEKL (BioLegend, 141603); PE-antiH-2Kb (BioLegend, 116508); APC/Cy7-anti-CD103 (BioLegend, 121431); FITC-anti-CD3 (BioLegend, 100203); BV711-anti-CD8a (BioLegend,100747); APC-anti-CD8a (BioLegend, 100712); PE-anti-CD8b.2 (BioLegend, 140408); PE-H-2D(b) MC38 Adpgk peptide tetramer (Helixgen, HG08T23002); PE-H-2k(b) OVA257-264 tetramer (Helixgen, HG08T14028); CFSE(BioLegend, 423801); PE-antiCD4 (BioLegend, 100408); APC-anti-IFN-γ (BioLegend, 505810); PE/Cy7-anti-IL-4 (BioLegend, 504117) 4. .. The following antibodies were used for Immunoblotting and immunodot-blotting: anti-STING (Cell Signaling Technology, 13647), anti-TBK1 (Cell Signaling Technology, 3504T), anti-pSTING (Cell Signaling Technology, 72971S), anti-pTBK1 (Cell Signaling Technology, 5483T), anti-GAPDH (Abbkine, ABL1020); streptavidin-HRP (Thermo scientific, 21130); anti-rat IgG, HRP-linked antibody (Cell Signaling Technology, 7077); anti-rabbit IgG, HRP-linked antibody (Cell Signaling Technology, 7074); anti-mouse IgG, HRP-linked antibody (Cell Signaling Technology, 7076); anti-calreticulin (Abcam, ab2907), Article Title: STING agonist-based ER-targeting molecules boost antigen cross-presentation Article Snippet: The following fluorescent conjugate-labeled antibodies were used: FITC-anti-CD11c (BioLegend, 117306); PE-anti-CD11b (BioLegend, 101207); APC/Cy7-anti-CD62L (BioLegend, 104427); PB-anti-CD44 (BioLegend, 156005); BV650-anti-CD127 (BioLegend, 135043); APC-antiCD24 (BioLegend, 138505); PerCP/Cy5.5-anti-CD172α (BioLegend, 144010) ; PE/Cy7-anti-B220 (BioLegend, 103222); PB-anti-CD86 (BioLegend,105007); BV421-anti-CD86 (BioLegend, 105032); APC-anti-H-2Kb-SIINFEKL (BioLegend, 141606); PE-anti-H2-Kb-SIINFEKL (1:100, BioLegend, 141603); PE/Cy7-anti-H-2Kb-SIINFEKL (BioLegend,141607); PE-anti-H2-Kb-SIINFEKL (BioLegend, 141603); PE-antiH-2Kb (BioLegend, 116508); APC/Cy7-anti-CD103 (BioLegend, 121431); FITC-anti-CD3 (BioLegend, 100203); BV711-anti-CD8a (BioLegend,100747); APC-anti-CD8a (BioLegend, 100712); PE-anti-CD8b.2 (BioLegend, 140408); PE-H-2D(b) MC38 Adpgk peptide tetramer (Helixgen, HG08T23002); PE-H-2k(b) OVA257-264 tetramer (Helixgen, HG08T14028); CFSE(BioLegend, 423801); PE-antiCD4 (BioLegend, 100408); APC-anti-IFN-γ (BioLegend, 505810); PE/Cy7-anti-IL-4 (BioLegend, 504117) 4. .. The following antibodies were used for Immunoblotting and immunodot-blotting: anti-STING (Cell Signaling Technology, 13647), anti-TBK1 (Cell Signaling Technology, 3504T), anti-pSTING (Cell Signaling Technology, 72971S), anti-pTBK1 (Cell Signaling Technology, 5483T), anti-GAPDH (Abbkine, ABL1020); streptavidin-HRP (Thermo scientific, 21130); anti-rat IgG, HRP-linked antibody (Cell Signaling Technology, 7077); anti-rabbit IgG, HRP-linked antibody (Cell Signaling Technology, 7074); anti-mouse IgG, HRP-linked antibody (Cell Signaling Technology, 7076); anti-calreticulin (Abcam, ab2907), |
